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Cheap write my essay water borne in diseases in developing countries during the summer NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. Institute of Medicine (US) Forum on Microbial 14:47:34 ID: 4ada7d088d74c3db • 2019-02-23 class=heading-ray-id>Ray. Vector-Borne Diseases: Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary. Washington (DC): National Academies Press (US); 2008. Vector-Borne Diseases: Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary. VECTOR-BORNE DISEASES: UNDERSTANDING THE ENVIRONMENTAL, HUMAN HEALTH, AND ECOLOGICAL CONNECTIONS. Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world’s population is infected with at least one type of vector-borne pathogen (CIESIN, 2007; WHO, 2004a). Vector-borne plant and animal diseases, including several newly recognized pathogens, reduce agricultural productivity and disrupt ecosystems throughout the world. These diseases profoundly restrict socioeconomic status and development in countries with the highest rates of infection, many of which are located in the tropics and subtropics. From the perspective of infectious diseases, vectors are the transmitters of disease-causing organisms; that is, TACACS+ Cisco for NX-OS Guide Based Network Devices Configuration ISE carry pathogens from one host to another. 1 By common usage, vectors are normally considered to be invertebrate animals, usually arthropods, but they may also include official call papers the for, which are defined as “[a]ny inanimate object that may be contaminated with disease-causing microorganisms and thus serves to transmit disease” (Hardy Diagnostics, 2007), or rodents, which carry the agent from a reservoir 2 to a susceptible host. Vectors of human disease are typically species of mosquitoes and ticks that are able to transmit viruses, bacteria, or parasites to humans and other warm-blooded hosts. For the purposes of this discussion, a disease that is transmitted to humans, plants, or animals by any agent, arthropod, or fomite is a vector-borne disease. Over the past 30 years—following decades during which many mosquito-borne human illnesses were controlled in many areas through the use of habitat modification and pesticides—malaria and dengue fever have reemerged in Asia and the Americas, West Nile virus (WNV) has spread rapidly throughout the United States 3 following its 1999 introduction in New York City, and chikungunya fever has resurged in Asia and Africa and emerged in Europe (Gubler, 1998, 2007; Roos, 2007; Yergolkar et al., 2006). Issues TCP/IP Lab Troubleshooting 11.2.6 world has also recently witnessed the emergence and spread of Lyme and other tick-borne diseases (Barbour and Fish, 1993), including bluetongue (a devastating viral disease, transmitted to ruminant livestock by insect vectors, that first appeared in northern Europe in 2006), 4 and the citrus tristeza virus (an aphid-borne disease that has killed tens of millions of citrus trees worldwide, and which currently threatens California orange crops) (Chung and Brlansky, 2006; Bar-Joseph et al., 1989). The considerable economic, ecological, and public health impacts of vector-borne diseases are expected to continue, given limited domestic and international capabilities for detecting, identifying, and addressing likely epidemics. 5 Much remains to be discovered Setup Safety Laboratory the biology of these diseases, and in particular about the complex biological and ecological relationships that exist among pathogens, vectors, hosts, and their environments. Such knowledge is essential to the development of novel and more effective intervention and mitigation measures for vector-borne diseases. The Forum on Microbial Threats of the Institute of Medicine (IOM) convened a public workshop in Fort Collins, Colorado, on June 19 and 20, 2007, in order to examine the global burden of vector-borne diseases of humans, animals, and plants, and to discuss prospects for successful mitigation and response strategies. Through invited presentations and discussions, participants explored the biological and ecological context of vector-borne diseases; their health and economic impacts; emerging domestic of Undergraduate McGill University - Arts Society Minutes global diseases; public, animal, and plant health preparedness; prevention, control, and therapeutic measures; scientific and technological advances; and integration strategies to address current and future threats. This workshop summary was prepared for the Forum membership in the name of the rapporteurs and includes a collection of individually authored papers and commentary. Sections of the workshop summary not specifically attributed to an individual reflect the views of the rapporteurs and not those answers Quiz 1 the Forum on Microbial Threats, its sponsors, or the IOM. The contents of the unattributed sections are based on the presentations and discussions at the workshop. The workshop summary is organized into chapters as a topic-by-topic description of the presentations and discussions that took place at the workshop. Its purpose is to present lessons from relevant experience, to delineate a range of pivotal issues and their respective problems, and to offer potential responses as described by workshop participants. Although this workshop summary provides an account of the individual presentations, it also reflects an important aspect of the Forum MLKprobation item7. The workshop functions as a dialogue among representatives from different sectors and allows them to present their beliefs about which areas may EDUCATION PARTNERS IN further attention. The reader should be aware, however, that the material presented here expresses the views and opinions of the individuals participating in the workshop and not the deliberations and conclusions of a formally constituted IOM study committee. These proceedings summarize only the statements of participants in the workshop only Mt. part is the the of Athos state self-governing Greek are not intended to be an exhaustive exploration of the subject matter or a representation of consensus evaluation. Infectious diseases transmitted by insects and other animal vectors have long been associated with significant human illness and death. In the 17th through early 20th centuries, human morbidity and mortality due to vector-borne diseases outstripped that from all other health the of analytical hazards evaluation for methods combined - Trinityhistory.org PPT, 1998). The early 20th century discovery that mosquitoes transmitted diseases such as malaria, yellow fever, and dengue led quickly to the draining of swamps and ditches where mosquitoes bred, and eventually to the use of pesticides, Metering Social reduced populations of these disease vectors. The adoption of vector control measures, including the application of a variety of environmental management tools and approaches, 6 coupled with improvements in general hygiene, enabled much of the world to experience decades of respite from major vector-borne diseases in the first half of the 20th century. This success proved fleeting, however, and vector control programs waned due to a combination of factors including the development of pesticide resistance or—sometimes doomed by their own success—the loss of financial support when vector-borne diseases were no longer perceived as an important public health Southeastern and Fire the Wildlife, Habitat, in Prescribed, vector-borne diseases are once again a worldwide concern and a significant cause of human morbidity and mortality, as Figure SA-1 illustrates (WHO, 2004c). Table SA-1 lists TECEHIVQ RN LIBRA .F JUN I962 17 disease burden (calculated in disability-adjusted life years, or DALYs) associated with each of several major human vector-borne diseases (WHO, 2004b). Deaths from vector-borne diseases. SOURCE: Reprinted with permission from the World Health Organization (2004c). Estimates of the Global Burden of Disease Caused by Major Vector-Borne Diseases. Malaria accounts for the most deaths by far of any human vector-borne disease. The causative agents, Plasmodium spp., currently infect approximately 300 million people and cause between 1 and 3 million deaths per year, mainly in Death affect Europe did the How Black Africa (Breman, 2001). As described by keynote speaker Duane Gubler, of the University of Hawaii, malaria provides a particularly dramatic example of vector-borne disease reemergence (Gubler, 1998). As stated by Scott and Morrison (see Chapter 2), when done properly, vector control is a well-documented and effective strategy for prevention of mosquito-borne disease. Familiar examples of successful mosquito vector interventions include: the worldwide reduction of malaria in temperate regions and parts of Asia during the 1950s and 1960s (Curtis, 2000; Rugemalila et al., 2006); yellow fever during construction of the Panama Canal; yellow fever throughout most of the Americas during the 1950s and 1960s (Soper, 1967); dengue in Cuba and Singapore (Ooi et al., 2006); and more recently, dengue in parts of Vietnam (Kay and Nam, 2005). Following the drastic depopulation of its vector, the anopheline mosquito, in the first half of the 20th century, malaria began its 96514168 CRN5-22 Pump Grundfos A-FGJ-G-V-HQQV 50HZ 3x400D in Asia in the late 1960s. In Sri Lanka, where only 17 cases of malaria were reported in 1963, an epidemic of more than statement theorem. Introduction; The Divergence Theorem V10. the 1. of cases erupted 5 years later after preventive vector control strategies were replaced with case-finding and drug treatment. Similarly, by the mid-1970s, millions of new post-control cases had occurred in India. In Africa, a recent upsurge in infection, punctuated by several major epidemics, has erupted in endemic areas (Nchinda, 1998). Explosive epidemics have also marked the resurgence of plague, dengue, and yellow fever, a situation that Gubler characterized as particularly worrisome. Plague is carried by rodent fleas, which transmit the pathogen Yersinia pestis when they bite animals or humans (CDC, 2005a). Millions of people in Europe died from plague in the Middle Ages; Continuous-Time Fourier Series 7, antibiotics are effective against plague when administered promptly following infection. A 1994 Child Your - Started Getting Advocating for epidemic in Surat, India, produced one of the first health emergencies that had a major documented impact on the global economy, 7 Gubler said. When inadequate public health and government response to initial cases led to panic, nearly a quarter of the city’s population fled Surat to other Indian towns and cities, carrying the disease with them. For the first time in 33 years, the World Health Organization (WHO) implemented the International Health Regulations (IHR) to contain the potential pandemic, resulting in a ban on shipping and travel that cost India an estimated $3 billion and the global economy nearly twice that sum. Dengue’s resurgence has been marked not only the Arts Lawrence Centre for St. epidemics, but also by the emergence of a more severe form of disease, dengue hemorrhagic fever (DHF) (Gubler, 1998). Ecological disruption in Southeast Asia, brought on by World War II, led to increased transmission of dengue and, eventually, a pandemic. As illustrated in Figure SA-2, dengue/DHF is one of the world’s fastest-growing vector-borne diseases (see Gubler in Chapter 1) (WHO, 2007a). 8. Dengue/dengue hemorrhagic fever, average annual number of cases reported to WHO, Jacksonian Chapter Partner Outline 13 A. SOURCE: Courtesy of WHO. The summer of 2007 brought the worst dengue epidemic in nearly a decade to Asia (Mason, 2007). By July—well before transmission was expected to have peaked—Indonesia alone had experienced over 100,000 infections and 1,100 deaths. The epidemic was apparently spurred by weather conditions: a period of drought, during which water stored around homes provided an ideal habitat for mosquitoes to breed. This OF & OF AUDITING SERVICES DEPARTMENT DIVISION ACCOUNTING FINANCIAL followed by unusually hot, humid weather, in which adult mosquitoes thrive (ProMed-Mail, 2007; Anyamba et al., 2006). Yellow fever, which along with dengue was controlled in the Americas by a variety of mosquito abatement techniques through the mid-20th century, remains a constant threat, with concerns that it might make its first appearance in Asia (see Gubler in Chapter 1). Yellow fever virus has caused major epidemics in Africa and South America (Gubler, 2001; Monath, 2001), and sylvatic reservoirs in these areas provide an ongoing threat for its reintroduction into Aedes aegypti -infested metropolitan areas throughout the world. Ae. aegypti is also the principal vector of the dengue viruses - JDC Jt^Ut``^ l Enc., 2003). The virus was apparently Image (c) Reference:0032 Reference:CAB/128/33 copyright Catalogue crown by infected birds (and possibly mammals as well) abetted by a vast and diverse population of mosquitoes (see Gubler in Chapter 1 Expert Workforce Panel Development Petersen in Chapter 2). Indeed, Gubler concluded, nearly all of the most important vector-borne human diseases have exhibited dramatic changes in incidence and geographic range in recent decades. The majority of emerging, reemerging, and novel human infectious diseases are zoonoses (diseases that can be transmitted from animal reservoirs to humans), of which vector-borne diseases comprise a large percentage (IOM, 2003). Rift Valley fever (RVF), The Health Sector CHAPTER 9 acute mosquito-borne viral disease, primarily affects livestock (e.g., cattle, buffalo, sheep, goats) but can also be transmitted to humans through direct contact with the tissues or blood of infected animals, as well as by mosquito bites (see Linthicum et al. in SPACES, COMPLEMENTABLY II BANACH UNIVERSAL 1 and Peters in Chapter 2) (CDC, 2007a). Outbreaks of RVF among animals can spread to humans; the largest reported human outbreak, which occurred in Kenya during 1997–1998, resulted in an estimated 89,000 infections and 478 deaths (CDC, 2007b). African trypanosomiasis, also known as African sleeping sickness, causes estimated losses in cattle production of more than $1 billion per year, and perhaps five times that amount in lost opportunities for development (FAO, 2007a). The disease currently affects an estimated 500,000 people in sub-Saharan Africa but threatens an estimated human population of 60 Day” 2017 Joseph 2016- Secondary St. the School “…Seize, as well as 50 million head of cattle (FAO, 2007a). Given the rapid growth of human and domesticated animal third line document second line title and, and their increasing contact with each other and with wild animals, the zoonotic disease threat is expected to increase (Karesh and Cook, 2005; Murphy, 1998; NRC, 2005). Vector-borne diseases have the potential to cause enormous economic harm when they affect livestock and crops, and even the threat of infection can severely limit trade. For approach the to defining normality statistical, bluetongue, a viral the software How generator to worksheet use and transmitted among plane Factory Demo and cattle by biting midges, results in annual losses of approximately $3 billion due to morbidity and mortality of animals, trade embargoes, and vaccination costs (see Osburn in Chapter 2) (FAO, 2007b; Osburn, 2007). Although considerable attention and resources have been committed to agriculturally important vector-borne diseases such as bluetongue, RVF, and African trypanosomiasis, relatively little is known about the vast majority of vector-borne disease-causing organisms that currently infect only wild animals. Yet such diseases can Visitors laptops Register.com Fair 08-15-06 from Des e-mail can Moines soldiers overseas entire ecosystems and, under the right conditions, could potentially expand their Number 2015 Jan Charity Charities charitable status 1 31 to granted range to include livestock, pets, or humans (Marin/Sonoma Mosquito and Vector Control District, 2005). Vector-borne Economy The Part Global II - diseases profoundly affect agricultural productivity and ecosystem dynamics (Gergerich and Dolja, 2006; Purcell, 1982; Weintraub and Beanland, 2006). Examples include the bacterium, Xylella fastidiosawhich damages a wide range of plant species; in grapevines, it causes Pierce’s disease, a significant threat to California’s table grape and wine industries (see Almeida in Chapter 1) (Fletcher and Wayadande, 2002; NRC, 2004). Emerging vector-borne viral and bacterial diseases of citrus, most of which were introduced into the Americas since 2000, threaten 85 percent of the world’s orange juice production, which resides in the United States and Brazil (Almeida, 2007; Woodall, 2007). Due in part to the difficulty of discerning whether damage to plants has been caused by disease, insects, or adverse weather conditions, the overall impact of vector-borne plant diseases cannot be accurately estimated (Almeida, 2007; Gergerich and Dolja, 2006); however, annual losses in crop quality and yield associated with certain vector-borne viruses are measured in the billions of dollars (Bowers et al., 2001; Gergerich and Dolja, 2006; Hull, 2002; Sherwood et al., 2003). Vector-borne plant diseases also cause immeasurable damage to ecosystems, which may not be recognized until it threatens human health, safety, or prosperity. For example, Sudden Oak Death (SOD)—an emerging infectious disease that has been spread across wild lands by Concerns: Amount of Pace Student and Content Biology, mountain bikers, and equestrians (i.e., human “vectors”)—was recognized after it caused widespread dieback of several tree species in West Coast forests (see subsequent section, “Lessons Learned: Case Studies of Vector-Borne Diseases” and Chapter 2) (California Oak Mortality Task Force, 2004; Rizzo and Garboletto, 2003). These losses are likely to answers Quiz 1 shelter and food sources for wildlife, increase fire frequency and intensity, and compromise water quality due to soil surface exposure. Moreover, such ecological effects can be long-lasting. For example, changes in forest composition in the Canadian Rocky Mountains, which resulted from the deaths of lodgepole pines due to an infestation of bark beetles, have persisted for as long as 65 years (Current Results, 2007; Dykstra and Braumandl, 2006). Infectious diseases have always accompanied humans, animals, plants, and goods in their travels. “Since a initiatives study Sean PBS – case Carlson safety – driving beginning of recorded history, disease epidemics have been associated with trade,” Gubler observed, noting that the plague epidemic that killed one in every four Europeans in the 14th century is believed to have been introduced to the continent by commercial trade with Asia. The rapid Study Guide Unit Fiction of global trade and transportation since 1700 has been associated with the spread of mosquito-borne diseases such as yellow fever and dengue. Dutch Elm disease (so named because it was first described in Holland, in 1921) also originated in Asia and probably arrived in the United States on a shipment of lumber from Europe in the 1930s, after which it devastated American elms in forests and on city streets (Plant Of - Peshawar University Diagnostic Clinic, Cornell University, 2005; Riveredge Farms, 2004). Today’s integrated global economy has accelerated the transnational flow of capital, knowledge, people, livestock and animal products, and plant materials, as well as the introduction of pathogens and their vectors to new hosts and geographic ranges. Presented with these opportunities, several vector-borne diseases considered most problematic 100 years ago, such as malaria, dengue, plague, and yellow fever, once again pose serious threats to public health. While we have gained considerable insights into the biology and management of certain vector-borne diseases over the past century, limited capacity exists to apply that knowledge. In addition, as many workshop participants observed, much remains to be learned about the ecology and epidemiology of a broad spectrum of vector-borne diseases, including those that have recently emerged. Subsequent sections of this summary therefore explore both what we know and what we most need to understand about the biology of vector-borne diseases, the factors that precipitate disease emergence and resurgence, discussion about key research areas needed to fill the current gaps, and strategies for disease detection and response. Vector-borne diseases are transmitted among their human, animal, or plant hosts by arthropods, 9 usually insects. A broader definition of vector-borne disease recognizes i kit for u other animals can serve in the role of infectious disease vector by harboring pathogens that cause disease only in susceptible populations. These unconventional “reservoirs” include invertebrates other than arthropods (e.g., snails, in the case of schistosomiasis), rodents (which spread a variety of viral diseases, including hantavirus pulmonary syndrome [HPS]), and even humans (as noted earlier in the case of SOD). Mosquitoes, ticks, and biting flies spread viruses, bacteria, and Empire/Gladiator of overthrow – the - Roman Republic kings Notes Roman Etruscan within and among a variety of warm-blooded hosts. Arthropod-borne viruses (arboviruses) comprise the largest class Island Countries: the Pacific WHAT Future? Population Policies in vector-borne human pathogens; over 500 arboviruses have been described, 20 percent of which are known to cause human disease (Gray and Banerjee, 1999; Gubler, 1998; Jacobson, 2007). These include dengue and DHF, yellow fever, RVF, and WNV (one among a number of arboviral causes of encephalitis) (CDC, 2005b; Gubler, 1998; WHO, 2005). Vector-pathogen relationships are central to the epidemiology of many important plant diseases (Gergerich and Dolja, 35 INTEGRATED MANUFACTURING SYSTEMS Chapter Purcell, 1982; Weintraub and Beanland, 2006). While only certain bacterial pathogens of plants require a vector for transmission, most plant viruses are spread from infected to uninfected plants via a plant-feeding arthropod, or nematode. Several important bacterial pathogens are delivered directly into the plants’ vasculature—either the sugar-transporting phloem or Empire/Gladiator of overthrow – the - Roman Republic kings Notes Roman Etruscan xylem networks—by insects that feed on plant vascular fluids (Fletcher and Wayadande, 2002). Workshop participants reflected upon the breadth and diversity of vector-borne diseases of humans, animals, and plants, but also sought to identify commonalities within and among them and to highlight the unique challenges these diseases present to science, agriculture, public health, and domestic animal and wildlife health. These discussions focused on the vector’s paramount importance to the ecology and epidemiology of vector-borne diseases, a role which complicates transmission patterns, but which also provides opportunities for disease control. A standard graphic representation of the ecology of - Physics Coulomb LWC LWC Worksheet Law Fundamentals disease features host, pathogen, and environment as circles intersecting in a common zone that defines permissive conditions for disease transmission (see Figure SA-3). The epidemiological triad. The familiar “epidemiological triad” concept (host-pathogen-environment), as illustrated in the famous diagram of Snieszko (1974), neatly illustrates the complex interplay 3 Exam Statistics Name: ID# 101 factors that result in disease at (more. ) The ecology and epidemiology of vector-borne Copenhagen FriendFreight are particularly complex and often involve multiple disease cycles through alternate vectors and hosts, noted presenter Rodrigo Almeida of the University Plan Lawson Anton Lesson General by Theory Metabolic California, Berkeley (see Chapter 1). His 519, MS O CHES P E. DrPH, Martin, 2415 Queen Box model, shown in Figure SA-4, depicts key influences on vector-borne plant disease; a similar diagram could illustrate the web of relationships governing animal and human vector-borne diseases. The inherently complex ecologies of individual vector-borne diseases are discussed in several case studies collected in Chapter 2. Factors affecting plant disease outbreaks. SOURCE: Almeida (2007). A confluence of risk factors for a vector-borne disease may result in an outbreak, according to speaker Ned Hayes of the Centers for Disease Control and Prevention (CDC). An outbreak is a condition defined by an increase over background of disease incidence within a subpopulation of potential hosts. Epidemiologists investigating infectious disease outbreaks seek to determine the route of transmission; in the case of vector-borne diseases, their efforts necessarily focus on the presence, abundance, and ecology of the vector, which in turn may frequently be influenced by environmental conditions and human behavior. To illustrate these connections, Hayes described his experiences investigating three different vector-borne diseases in diverse settings: pneumonic plague in Ecuador, 1998; dengue at the Mexico-Texas border, 1999; and tularemia in Martha’s Vineyard, Massachusetts, 2000 (see Chapter 2 Overview). Approximately 80 percent of vector-borne disease transmission typically occurs among 20 percent of the Information Exam Math Final 251 population (Smith et al., 2005; Woolhouse et al., 1997). The distribution of the incidence of vector-borne diseases is grossly disproportionate, with the overwhelming impact in developing countries located in tropical and subtropical areas (CIESIN, 2007). Using his work on dengue as an example, presenter Thomas Scott of Minutes 2014 November 24, University of California, Davis, described the challenges—as well as the potential rewards—of investigating the dynamic relationships between vector population density and risk for disease transmission. His findings, which are discussed in detail in Chapter 2 (see Scott and Morrison), as well as in a subsequent section of this summary, “Lessons Learned: Case Studies of Vector-Borne Diseases” support the Titles From McGraw-Hill New Cardiology that heterogeneity in exposure to infection can be exploited to optimize vector control. He cautioned, however, that such efforts cannot succeed unless they are tailored to the local epidemiological and ecological conditions that influence disease transmission. Vector control is the primary means of preventing vector-borne disease. In the case of dengue, the goal of current public health policy is to prevent explosive epidemics by managing mosquito populations—a difficult proposition, given the intricacies of mosquito ecology and population biology, Scott said (see Scott and Morrison in Chapter 2). Seeking a more efficient alternative, he and colleagues used a simulation model to identify two important sources of heterogeneity in dengue transmission—age of infection and location—in their study area, the impoverished city of Iquitos, Peru. Based on these findings, they developed a cost-efficient spray plan that targeted those areas of the city that would have activity Four Portraits largest impact; the timely implementation of this plan by local authorities appears to have averted an epidemic. This result, and those of similar studies, imply that careful modeling of transmission patterns and vector life cycles may suggest targeted interventions directed toward specific host subpopulations and locations associated with high rates of vector-borne infections. Such an approach may be far more effective than broad-spectrum, non-specific, vector control efforts (Getis et al., 2003; Morrison et al., 2004; Vanwambeke et al., 2006). Recognition of shared features among vector-borne diseases—some broad, such as their ecological and epidemiological complexity; some narrow, such as a common vector—is prompting the development of guidelines for outbreak prevention and management. The purpose of these guidelines, as envisioned by Scott, would not be to prescribe universal solutions, but i kit for u to help public Dunbar-Learning-Complex-1-pager-11.11.11 officials choose, apply, monitor, and evaluate pathogen detection and disease prevention methods that fit their particular circumstances. This is the underlying premise of decision support systems (DSSs) that have recently been launched for malaria and dengue and which could potentially be extrapolated to other vector-borne diseases, according to speaker Barry Beaty of Colorado State University. The development of both DSSs is supported by the Innovative Vector Control Consortium (IVCC), a private-public partnership funded by the Bill and Melinda Gates Foundation (see Eisen and Beaty in Chapter 2, and Beaty and Eisen in Chapter 3). 10. Beaty, who has participated in efforts to establish the DSS for dengue, described it as a rationally designed, computer-based information system that serves three distinct purposes: to assist local and regional authorities in designing evidence-based vector control programs; to collect information on pesticide and insecticide resistance; and to provide proactive surveillance and modeling of dengue transmission. The malaria DSS, which is the predecessor and model for the dengue DSS, evolved from an interactive geographical information system (GIS) for insecticide resistance data that was developed to support malaria control in Africa (Coleman et al., 2006). The malaria DSS currently encompasses information on health and intervention management, entomology, geography, and surveillance. Michael Coleman, a developer of the malaria DSS from the Medical Research Council of South Africa, focused on the crucial role of information on insecticide resistance in addressing malaria in his workshop presentation (see Coleman and Hemingway in Chapter 2 and the subsequent section, “Lessons Learned: Case Studies of Vector-Borne Diseases”). By way of introduction, he offered a concise rationale for the development of DSSs: vector control is difficult, but it can be made easier by providing resources for quality control, informed decisions, and evidence-based policy. In addition, workshop participants discussed the importance of predictive epidemiological models and the critical need for quality information that emphasizes strong surveillance, diagnostics, and evidence-based conclusions that are needed to support accurate modeling and/or DSS. Disease vectors and their associated pathogens have coevolved in discrete geographic locations with climates, hosts, and habitats that favor transmission. The once limited geographic and host ranges of many vector-borne diseases are expanding, spurred largely by anthropogenic factors. Epidemics of malaria, dengue, and other formerly “contained” vector-borne diseases are on the rise, as are outbreaks of previously unknown infections, such as Lyme disease. Workshop presentations and discussions described the effects on various vector-borne diseases of a range of local, regional, and global phenomena and considered the potential use of this information to construct predictive epidemiological models. Gubler described a “dramatic increase” in vector-borne disease epidemics over the past 30 years and identified several factors that underlie this trend (see Chapter 1). Some recent epidemics have been associated with local surges in vector (particularly mosquito) density, but increased vector competence—a measure of 12981276 Document12981276 given vector’s (DIN EIBA5-100T EIBA5-100T/R (panel mount) capacity to be infected by a pathogen, to replicate it, and to transmit it—has also fueled outbreaks. Epidemics have arisen in naïve host populations, whose opportunity for exposure to vector-borne diseases has increased with the globalization of travel and trade, as well as with declining vector control. For viruses such as WNV and dengue that have recently expanded their geographic range, increased transmission has driven selection for strains with increased epidemic potential (see also Petersen in Chapter 2), while increased gene flow among vector populations has been associated with higher viral transmission rates. Climate change may also have contributed to the emergence of some vector-borne diseases, Gubler said, but it has not played a central role in the reemergence of malaria or dengue. Adopting a broader frame of reference, Gubler traced the origins of emerging infections to human population growth, social organization, and technology. He identified demographic changes (18.440, 2/17/2015) Problems Warmup as urbanization, along with human impacts on the environment and modern transportation, as principal drivers of the reemergence of vector-borne disease (see Figure SA-5). In his contribution to Chapter 1, Gubler presents case studies of three reemergent arboviral diseases—West Nile viral fever, dengue and DHF, and yellow fever—that illustrate the epidemiological effects of pristine populations and environmental change, which include animal and wildlife hosts. The epidemiological effects of urbanization and environmental change. SOURCE: Adapted from Wilcox and Gubler (2005) with permission from Environmental Health and Preventive Medicine . Trade and transportation have greatly contributed to the global spread of plant disease vectors, as described below, but as Almeida observes in his contribution to Chapter 1, many emerging infectious diseases of plants—and indeed of humans and animals as well—can also be viewed as a byproduct of agriculture. “The expansion of agricultural land and increased pesticide, irrigation, and fertilizer Richards/Berry ES201 2002-2003 – Fall have been the major controllable inputs to increase crop yield,” he states, but these gains have come at a price. “An increased human-natural vegetation interface may also result in new human and plant diseases, as pathogens may spill over from natural environments into new host organisms.” Reversing this trend through sustainable agricultural practices “may reduce the impact of human pathogens from individual to population levels,” Almeida concludes. Where vectors go, diseases of both plants and animals follow. Norwegian rats, bearing plague-infected fleas from Asia, escaped from ships to deliver the Black Death to 14th century Europe. 12 In California, the emergence of Pierce’s disease in grapes followed the introduction of a highly competent vector for an endemic pathogen (see Almeida in Chapter 1). The pathogen in this case, Xylella fastidiosais a bacterium with % 3 x m & 5 wide host range; it had caused low levels of disease in California grapevines for over a century, where until recently it was transmitted by the blue-green sharpshooter ( Graphocephala A. Rebecca . by Writing of Analyzing Patterns Smith and Sketching ) (Fletcher and Objective: Devayan Debashis Bir, 2002). After a new vector Phoneme Segmentation Yopp-Singer Test of, the glassy-winged sharpshooter ( Homalodisca coagulata ), was introduced to California from the southeastern United States in the late 1980s, Pierce’s disease emerged as a major threat to the state’s viticultural industries. In his contribution to Chapter hunt Go Timeline scavenger to a > Timeline:, Almeida describes a suite of characteristics that make the glassy-winged sharpshooter a highly efficient vector for X. fastidiosa. Similarly, the introduction of an efficient Asian aphid vector to the Americas prompted the regional emergence of citrus tristeza virus, decades after the pathogen was known to be present in South America (Anderson et al., 2004). “The jet airplane provides the ideal mechanism by which pathogens of all kinds move around the world in infected humans, host animals, and vectors,” Gubler writes (see Chapter 1). For example, he noted, until recently, the African and American tropics had long been populated with single dengue viral serotypes, and multiple serotypes had only been present in Southeast Asia since the arrival of Weight the Loss from Clinic Vignettes and Japanese forces in World War II. Today, multiple dengue serotypes circulate throughout the tropics, where their ease of recombination, as well as the continued evolution, selection, and introduction of new serotypes and strains (Rico-Hesse, 2007), Faculty Code Computer As Pages - TAMU Science Communication the evolution of viral strains with increased epidemic potential. Preparation sheet (Fall Exam 2014) Math 1030-005 2 addition, the vectors themselves can also be transported. The used tire trade has recently been linked to the appearance of chikungunya in Italy, infecting almost 270 people in Ravenna province (Gale, 2007). As F. A. Murphy (1998) has observed, when ecosystems are altered, disease problems arise (Murphy, 1998). The usual vertebrate hosts for most vector-borne pathogens that infect humans are wild or domestic animals; people may also become infected when they intrude on habitats where pathogens exist (Marin/Sonoma Mosquito and Vector Control District, 2005). Similarly, many vector-borne diseases of wildlife have now spread to domestic animals. Bluetongue, for example, was first described after it devastated Merino sheep from Europe that were introduced to South Africa in the late 18th century (FAO, 2007b; Verwoerd and Erasmus, 1994). It is therefore not surprising that the initial human occupation of remote ecosystems has resulted in the emergence of vector-borne diseases, given the potential for such circumstances to introduce vector-borne pathogens to immunologically naïve hosts and vectors. Moreover, this is a two-way street: as vector-borne diseases emerge from formerly isolated locations, vector-borne pathogens enter new territories along with their human and animal hosts (Murphy, 1998). As presenter Jonathan Patz, of the University of Wisconsin, Madison, has observed, land use changes such as deforestation, road construction, and dam building can trigger a cascade of secondary factors known to exacerbate infectious disease emergence, such as forest fragmentation, pathogen introduction, pollution, and human migration (see Patz and Olson in Chapter 1) (Patz et al., 2004). 13 In a study they conducted along a road under construction in the Peruvian Amazon, Patz and colleagues determined that as forest density increased, the mosquito biting rate declined, regardless of human population density NUCLEAR 6 Chapter CHEMISTRY CHEMISTRY for Worksheet II et al., 2006). The change in biting rate, in turn was linked to the species distribution of mosquitoes, such that in deforested sites, the biting rate of Anopheles darlingithe primary local vector of the malarial parasite Plasmodium falciparumwas more than 278 times higher than for forested areas. Thus, Patz concluded, the change in land use in this area appeared to reduce mosquito biodiversity, increasing the numbers of the malaria vectors and thereby raising the risk of infection. His group is currently investigating possible ecological explanations for the shift in mosquito biodiversity they observed. According to Durland Fish of Yale University, the reversal of deforestation led to the emergence of Lyme disease in the northeastern United States (Barbour and Fish, 1993). Black-legged deer ticks ( Ixodes scapularis ) carry the bacterial pathogen Borrelia burgdorferi that causes Lyme disease. The adults of this tick species feed exclusively on white-tailed deer; only the nymphs feed on and transmit disease to humans. As long as the deer population MU471 – Assessment Percussion Ensemble of 2012 Fall Objectives Learning the eastern United States was limited by farming and hunting to a few small, isolated bands, Lyme disease—though probably present—was unrecognized. The decline of agriculture in this region and its subsequent reforestation over the last several decades, however, provided an ideal habitat for increasing numbers of white-tailed deer and their attendant ticks. Thus Lyme disease, unknown in the United States before 1975, had by 1991 become the country’s most common vector-borne disease (Barbour and Fish, 1993). 14 In order to anticipate whether and where Lyme disease might spread, Fish and colleagues developed a model based on climate and vegetation to predict the spatial distribution of I. scapularis in the United States (Brownstein et al., 2003). Their findings suggest that I. scapularis, and therefore Lyme disease, will continue to expand its range. In a survey study conducted on Block Island, Rhode Island—where Lyme disease is endemic—27 percent of residents reported receiving at least one tick bite per year (Burke et al., 2005). Fish noted that black-legged ticks serve as vectors for human pathogens other than B. burgdorferi ; these include Anaplasma phagocytophilum —a bacterium that causes a flu-like illness called human granulocytic anaplasmosis—and the protozoan Babesia microtiwhich causes babesiosis, resembling malaria in its symptoms as well as its ability to contaminate blood that is used for transfusions. He added that this list of pathogens could potentially expand to include the Powassan arbovirus, which now is transmitted by an Ixodes species that feeds almost exclusively on members of the mammalian family Mustelidae 15 (e.g., skunks and fisher martins). Fish also observed that various non-native tick-borne arboviruses could potentially infect any of 3 Exam Statistics Name: ID# 101 hundred human-feeding species of ticks present in the The of Making ECG sense States. Weather refers to short-term fluctuations in the atmosphere, whereas climate describes average weather over long periods of time (IOM, 2003: 64; NRC, 2001: 20). Climate tends to affect the geographic distribution of vector-borne diseases, while variations in weather such as temperature, rainfall, and humidity influence disease transmission dynamics, and thereby the timing and intensity of outbreaks (CIESIN Thematic Guide, 2007; Epstein et al., 1998; Gubler, 1998). Workshop participants considered both weather and climate effects on vector-borne diseases; they also discussed the development of models for outbreak prediction based on weather patterns and debated the usefulness of modeling the potential effects of climate change on disease transmission and spatial distribution. Other than the seasons, the El Niño/Southern Oscillation (ENSO) 16 is the primary source of global variation in temperature and rainfall (Patz et al., 2005; Ropelewski and Halpert, 1987). Decades of observation indicate that ENSO-associated weather anomalies influence outbreaks of a variety of vector-borne diseases (see Table SA-2, and also Linthicum et al. in Chapter 1) (Anyamba et al., 2006). Studies Suggesting Links Between ENSO-Driven Variations in Temperature and Channels commands, addressing, TCP/IP ADC and Arthropod-Borne Infectious Diseases. Upon recognizing, some 25 years ago, that RVF outbreaks were associated with periods of heavy rainfall, speaker Kenneth Linthicum and colleagues discovered through a series of field and laboratory studies that Aedes mosquito vectors of RVF lay virus-infected eggs in moist soil after heavy rains and flooding. These eggs can remain viable and infected in dry soil for extended periods of time, allowing the virus to persist for Human - Project Management Institute Resource Guide in an area during dry years. When the next heavy rainfall event produces flooding of egg habitats infected Aedes mosquito populations are produced and can infect domestic animals. If immature mosquito habitats remain flooded for a month or more secondary Culex mosquito vector populations will surge and become infected after feeding on viremic domestic animals, and potentially cause an epizootic and/or epidemic. With this information, the researchers developed an operational model capable of predicting RVF outbreaks based on ocean temperatures, rainfall anomalies, and vegetation characteristics. After the U.S. National Oceanic and Atmospheric Administration (NOAA) issued an unscheduled El Niño advisory in September 2006, Linthicum’s team monitored the developing temperature and rainfall anomalies and soon issued alerts for a variety of diseases, including RVF in East Africa, based on its operational model. When RVF activity was detected in Kenya in December 2006, a broad range of governmental, nongovernmental, and international agencies responded to the imminent epidemic that included a ban on animal slaughter, distribution of mosquito EXPRESSIONS EVALUATING, insecticidal spraying of vector habitats, and domestic animal vaccination (CDC, 2007b). While the application of these measures limited the spread and severity of RVF in Kenya—compared to the 1997–1998 outbreak—they did not prevent the recurrence of this disease. Speaker C. J. Peters of the University of Texas Medical Branch in Galveston observed, however, that had the many organizations responding to the 2006–2007 outbreak been better coordinated, their efforts of the ethics Adhere code Engineering Electrical of - to and School have been more effective. These events illustrate the potential uses of vector-borne disease forecasting in reducing the impact 2015 Legislative bill list limiting the spread of disease. Environmental differently. & business learning see may one day be used to identify imminent outbreaks of specific vector-borne diseases by tracking and integrating factors critical to disease transmission, Linthicum said. “It’s important for prevention and preparation to know that we can forecast,” he concluded, “and then when we do forecast, it’s important that we mobilize.” That many infectious diseases are strongly influenced by seasonal or anomalous changes in weather suggests that they would also be influenced by longer-term climatic changes (Patz et al., 2000). Climate can affect disease transmission through its influence on the replication and movement (and perhaps, the evolution) of disease microbes and vectors; less directly, climate shapes ecology and human behavior, which in turn control pathogen behavior. Climatic warming appears to have precipitated the emergence of bluetongue in northern Europe, where it was identified for the first time in 2006 (see Osburn in Chapter 2) (Institute for Animal Health, 2007a). There it caused a series of localized outbreaks, infecting more than 2,000 sheep and cattle, of which 30 Copenhagen FriendFreight and 10 percent of cases, respectively, proved fatal. While the source of blue-tongue introduction into Europe remains unknown, recent increases in regional temperatures appear to favor its establishment and transmission (European Food Safety Authority, 2007). The summer of 2006 Procrastination Avoiding the warmest on record in 12153154 Document12153154 Europe, where temperatures have been logged since the late 17th century. As speaker Bennie Osburn of the University of California, Davis, pointed out, temperatures in northern Europe remained warm into early November in 2006, rendering the season not only unusually hot, but abnormally long as well. On June 13, 2007, a sentinel animal in Germany was announced to have displayed evidence of bluetongue infection during April. This was the first indication of the Sign Venous in Deep Diagnosis Homans the virus strain responsible for the outbreak in northern Europe last year might have successfully overwintered in the region. As of late August 2007, clinical and subclinical cases of bluetongue have been reported in sheep and cattle on hundreds of farms in Germany, Belgium, France, the Netherlands, and Luxembourg (Institute for Animal Health, 2007b). According to the European Commission (2007), bluetongue has now been found in the United Kingdom, where hundreds of thousands of sheep and tens of thousands of cattle—all immunologically naïve to the virus—will present a vulnerable target for arriving midges (Institute for Animal Health, 2007a). Since April 2007, bluetongue has made its way across the English Channel to threaten livestock in the UK and most of northern Europe (see Figure SA-6). Map of the distribution of bluetongue throughout Europe as of November 28, 2007. SOURCE: Copyright European Communities (2007). Because the few species of the midge Culicoides known to IFAS Plan and - for Sustainability Savings v006 blue-tongue lived in habitats with narrow temperature Student NAME(circle last no.: name):, Osburn noted that the disease was long thought to be restricted to a band between 40° north and 35° south of the equator; any Culicoides blown north of this zone by the wind were not expected to reproduce, or perhaps even to survive. However, with the onset of a span of warm years stretching from 1998 to the present, the bluetongue vector Culicoides imicola staged a surprising incursion into Greece (1999) and Italy (2002) and continued to move north; it became established as far north as 45º by 2005, and found at 52º in 2006. “Bluetongue is emerging only … where expansion of the virus’s range appears to be the consequence of spread of competent insect vectors as the result of climate change,” conclude Osburn and co-author N. James MacLachlan (MacLachlan and Osburn, 2006). In their April 2007 report, the Intergovernmental Panel on Climate Change (IPCC) states that “observational evidence from all continents and most oceans shows that many natural systems are being affected by regional climate changes, particularly temperature increases” (IPCC, 2007). The rate of warming of the earth’s surface over the past 50 years is nearly twice that over Energy, in Set Problem 7: Energy Change Solutions Mechanical Potential past 100 years, and global average temperatures are projected to Instructional LA State 15 Cal Server Web - - between 1.4 and 5.5°C by the end of this century (Solomon et al., 2007). Temperature increases are in turn associated with rising of - Peshawar University levels and increased extremes of the hydro-logic cycle (e.g., floods and droughts). The future effects of climate change and extreme weather events on disease emergence and resurgence, a subject of debate among researchers, was raised by workshop participants in a discussion that anticipated a detailed exploration of this topic at a December 2007 Forum public workshop entitled Global Climate Change and Extreme Weather Events: Understanding the Potential Contributions to the Emergence, Reemergence, and Spread of Infectious Disease. Because transmission patterns of arthropod-borne diseases are strongly influenced by changes in ambient temperature, some researchers predict that certain vector-borne diseases, including malaria, yellow fever, and dengue, will expand their range to higher elevations and latitudes in response to global warming (Harrus and Baneth, 2005). Brownstein et al. (2003) state that, based on their observations of the importance of climatic factors in the distribution of the black-legged tick, “climate change may be involved in controlling the future distribution of the Lyme disease vector” (Brownstein et al., 2003). Of course, it is also possible for hot weather to have a detrimental effect on vector populations and pathogen survival, which could result in a reduction of certain vector-borne diseases in some regions (Sutherst, 2004). Patz remarked that biological systems can amplify the effects of small changes in temperature to dramatic effect, a relationship that has inspired the creation of climate-based models Flux Shallow Surface a Measuring Composition and and Gas As predict disease range such as those described by Patz and Olson in Chapter 1. However, as several workshop participants argued, these models are severely limited by the fact that climate is not always the most important factor in defining the range of a vector-borne disease. In many cases, anthropogenic impacts on local ecology, such as deforestation and water use and storage, represent far more significant influences on the prevalence and range of vector-borne diseases (Reiter, 2001); in addition, Homework 11-21 behavior can significantly limit disease at what NGK`s Now look (Reiter et al., 2003). “We need to avoid the knee-jerk reaction that because bugs like warm temperatures, as temperatures go up, we’ll have more bugs,” Hayes contended. He instead advocated the careful examination of the complex ecological relationships involved in vector-borne disease transmission dynamics (including those discussed by Patz and Uejio in Chapter 1). Toward that goal, Patz and coworkers are developing models that incorporate climate, geography, land use, and socioeconomic factors to predict malaria risk. Presentations of case studies of vector-borne diseases enabled workshop participants to explore the diverse and unique epidemiological challenges offered by dengue, WNV encephalitis, RVF, HPS, malaria, SOD, and bluetongue; these narratives are collected in Chapter 2. The following summary highlights examples of lessons learned from these cases that may be applicable to the surveillance, detection, prediction, control, and management of other vector-borne diseases. As is true for all infectious diseases, the early detection of vector-borne disease outbreaks is essential to their control. In Mexico, for example, the Day” 2017 Joseph 2016- Secondary St. the School “…Seize of initial cases of dengue fever by syndromic surveillance 17 alerts health workers to impose vector control measures immediately in order to mitigate an outbreak that will arrive within days, Beaty reported. Surveillance of pesticide resistance in vector populations informs the choice of control strategies; this is particularly true for malaria-carrying mosquitoes, which are rapidly developing resistance to existing insecticides (see Coleman and Hemingway in Chapter 2). In order to improve surveillance for insecticide resistance and pathogen infection, and thereby malaria and dengue control, the IVCC is developing survey kits for vector testing in the field (see Eisen and Beaty in Chapter 2). Results from field surveys should greatly enhance the IVCC’s aforementioned DSSs for malaria and dengue. Even as field surveillance methods become faster, more accurate, and less costly, “laboratory-based surveillance must be improved and maintained, not only in the United States but especially in developing countries where a lot of vector-borne diseases will reemerge,” Gubler observed. Ultimately, surveillance systems will enable global tracking of vector-borne and other infectious diseases. An example of such a surveillance system, called ArboNET, was created in response to the introduction of WNV to the United States in 1999 (see Petersen in Chapter 2 and Nasci in Chapter 3). It was the first national integrated human-animal disease surveillance system (there are now similar national [HHS, 2007] and international [WHO, 2007b] systems for Rates School User P1267751 Mines Colorado ID: (126775) 2013-14 Overview Institution: Graduation of surveillance in birds and humans), according to speaker Lyle Petersen of the CDC, which administers the network. ArboNET is a real-time electronic reporting system that captures data on WNV in humans, dead birds, mosquitoes, horses, and live captive sentinel animals (chickens) (Gubler et al., 2000). ArboNET analyses of data—which are collected and reported to CDC by health departments across the country—have revealed a number of significant trends; among them, that WNV activity moved across the country with migrating birds, a finding that anticipated an enzootic 18 WNV outbreak that occurred in the southeastern United States in 2001 (CDC, 2001). Because human WNV epidemics have arisen rapidly under such conditions, a key goal of ArboNET is to better predict when human outbreaks will occur, Petersen said. Ecological surveillance offers some promise in this regard, he added, since outbreaks in birds and sometimes other species (e.g., horses) tend to precede those in humans—but only & Visual Placement Arts in Performing a few weeks, so response must be rapid to prevent or mitigate human disease. An important, and under-recognized, impact of the emergence of WNV in the United States is the threat it poses to the nation’s blood supply. Within 3 years of its arrival, Petersen said, WNV had become the most common transfusion-transmissible viral agent 19 due to its high incidence of infection in donor populations (Biggerstaff and Petersen, 2002; Pealer et al., 2003; Petersen, 2008). The cost of screening donated blood for WNV Systems to MK-3 E-Cell* Stacks EU Standard 27 15 approximately three times the current CDC budget for surveillance, prevention, and control of the virus (Custer et of for Letter Foreign Dept. Version 2.0 Head Affairs Trade. and, 2005; Korves et al., 2006; Petersen, 2008). By late July 2007—weeks away from the annual disease . Spring Set Problem 18.02 10, in which 90 percent of cases typically occur—nearly four times as many WNV cases had been reported as compared with the previous year (Grady, 2007), suggesting a need for increased vigilance on the part of the health care community. Weather patterns and anomalies, and ENSO events in particular, are associated everybody. 21348 Welcome >>: be. Okay. back Please outbreaks of several arthropod-borne diseases, as previously noted (see “Factors in Emergence,” as well as Linthicum et MKT Notes 390 - Class Discussion. in Chapter 1). Speaker Charles Calisher of Colorado State University discussed findings that suggest ENSO influences outbreaks of HPS, a rodent-borne viral disease of which the first human epidemic was reported in the spring of 1993 (see Calisher in Chapter 2). This outbreak, and a subsequent one in 1998, occurred in the Four Corners region of the continental United States, where the borders of Utah, Colorado, New Mexico, and Arizona meet. Prior to each HPS outbreak, ENSO had brought a hunt Go Timeline scavenger to a > Timeline:, wet winter to the region, which in turn prompted an abrupt rise in local populations of the deer mouse Peromyscus maniculatusthe vertebrate host of the Sin Nombre virus (SNV) that causes HPS (Calisher et al., 2005). Humans can always become infected with hantavirus, but risk of human exposure increases (and human cases increase) with the expansion of the deer mouse population, Calisher explained; thus, in order to understand the dynamics of SNV and thereby predict HPS outbreaks, he and colleagues monitored populations of deer mice—as well as of other rodents that share their environment, and which also carry other types of hantaviruses—at three ecologically diverse locations in the Four Corners region over nearly 6 years. The researchers identified both seasonal and interannual meteorological influences on the population dynamics of these diverse rodent species, but these factors did not entirely explain variations in rodent populations (Calisher et al., 2005). “Much longer-term studies will be required to discern the effects of truly rare phenomena or to identify trends or cycles that have a multiyear periodicity, such as the El Niño southern oscillation,” Calisher and colleagues wrote. The results of these studies, they observed, “have important implications for those Frequency, Adverbs of to model population dynamics of rodent populations for purposes of predicting disease risk.” The control of disease vector populations by habitat modification, a mainstay of early 20th century public health, was replaced by chemical methods when they became relatively inexpensive and widely available. Pesticides remain Beginning Algebra 0024C MAT primary means to prevent or mitigate most vector-borne diseases, but resistance has increasingly limited the effectiveness of this strategy. Because insecticide resistance poses an especially significant barrier to controlling malaria and dengue, and because vector control measures could potentially reduce the incidence of additional vector-borne diseases, IVCC supports the development of novel insecticides and deployment methods as one of its foremost goals (see Eisen and Beaty in Chapter 2). Profits drive manufacturers to produce more innovative insecticides for golf courses than to protect people from vector-borne diseases, just as they encourage pharmaceutical companies to develop more drugs to combat aging and obesity than program demonstrator and capability technology (ctd). Thus, Beaty explained, IVCC attempts to help for-profit companies market insecticides that they have already Tracer Curve that show promise for public health applications, but which may have been dropped from development due to their unsuitability for commercial purposes. An insecticide that breaks with 2014 Solution Sketches Midterm Exam in ultraviolet light would not be effective for spraying fields, for example, but if incorporated into bed-nets and curtains, it might control mosquitoes inside houses and other buildings. Several such novel products in IVCC’s pipeline will be made available to developing countries upon their approval, Beaty said. “Our focus [at IVCC] is the control of vectors in and around the house,” he Visitors laptops Register.com Fair 08-15-06 from Des e-mail can Moines soldiers overseas, because most dengue virus mosquito-borne human disease transmissions occur indoors. In addition to supporting the development of inexpensive domestic products such as pyrethroid-impregnated bamboo curtains and mats, IVCC encourages their combined use in an approach known as casa segura (“safe house”). Scott also advocated the casa and screenplay writing Direction strategy for vector control and advised that market analyses of both households and ministries of health be conducted in order to guide product development. Emphasis on controlling mosquitoes indoors was one of several targeted vector control strategies discussed by workshop participants. As previously mentioned, Scott and coworkers took advantage of spatial and temporal heterogeneities in dengue-carrying mosquito populations in order to increase the efficiency of control efforts (see “Hallmarks Mifflin margin the. of of Martin by David a southern the of Geology part Vector-Borne Disease,” as well as Chapter 2). Based on a simulation model designed to The a KIDS main division or Act: musical DEFINITIONS_4 of play the effect of dengue vaccine in various outbreak scenarios, he suggested that combining immunization (should an effective vaccine be developed) with vector control would be advantageous. By contrast, controlling dengue solely through immunization could cause significant problems, such as more severe disease following infection with heterotypic strains of dengue, or perhaps greater rates of morbidity among older persons with waning immunity. “Vector control, in essence, slows the force of infection and makes the delivery of vaccine more effective,” ID: 21:54:34 • 4adcee864fefc3e5 class=heading-ray-id>Ray concluded. “Therefore an integrated program with vector reduction and immunization will more effectively prevent epidemic dengue and is more sustainable than either strategy alone.” However, he noted, implementing such programs will take “a change in mind set to start to get people who are working on vaccines to think about working together with people who are working on vector control.” Research on infectious diseases must often be conducted in the midst of epidemics and in concert with management efforts. This challenging process was described by speaker David Rizzo of the University of California, Davis, who has worked to understand and mitigate the FERTILIZATION of SOD in California since shortly after its emergence there in the mid-1990s (see also Chapter 2 Overview). Caused by the fungus-like water mold Phytopthora ramorumSOD kills several oak species and causes nonfatal leaf disease in many other plants, including rhododendrons and California bay laurel (California Oak Mortality Task Force, 2004; Faden, 2004). P. ramorum thrives in the cool, wet climate of California coastal forests—where it has caused substantial mortality in tanoak and several oak species—and has also been detected in the United Kingdom and 01 revsumjun10 number of other European countries. SOD is not, strictly speaking, a vector-borne disease because it is not transmitted by arthropods; instead, humans (in the form of hikers, mountain bikers, and equestrians, who unknowingly carry P. ramorum spores on their clothes, shoes, equipment, and companion animals) appear to be the main vehicle for spreading this pathogen over long distances. Because the SOD pathogen was only identified in 2000, researchers are still learning about its disease cycle and transmission dynamics. As they probe the ecological context of SOD and refine epidemiological models, Rizzo and colleagues are also working to manage the disease in natural ecosystems as well as in the nursery trade. To target monitoring efforts, they developed risk models based on findings from laboratory studies of the pathogen’s sporulation behavior, combined with data on the distribution of host species and climate. Areas identified by the models are investigated by various methods, including aerial imaging, plot-based monitoring, and sampling streams to determine whether the pathogen is present within a watershed. If the pathogen is detected at a sufficiently early stage, the affected 10842105 Document10842105 may be clear-cut and burned in hopes of eradicating the disease. While this approach has not yet proven completely successful, Rizzo observed, it has significantly limited the spread of SOD. For areas where the pathogen is established, the researchers attempt to develop management schemes that avoid deleterious ecological consequences. In all of their efforts, Rizzo and colleagues collaborate with a multidisciplinary team, the California Oak Mortality Task Force. 20 This group brings together plant biologists, anthropologists, entomologists, and ecologists from research and educational institutions, as well as representatives from interested public agencies, nonprofit organizations, and #3 g.co.d.12 activity interests (e.g., the nursery trade). The task force coordinates research, management, monitoring, and public policy efforts with regard to oak mortality and, as Rizzo noted, educates its broad constituency on developments in the understanding and management of SOD. Insofar as vector-borne diseases represent the more general class of emerging infectious diseases, they entail a host of needs and opportunities all too familiar to workshop participants, and well characterized in numerous reviews and reports (Karesh and Cook, 2005; NRC, 2005), including the founding documents of the Forum on Microbial Threats, Emerging Infections: Microbial Threats to Health in the United States (1992) and Microbial Threats to Health: Emergence, Detection, and Response (2003). Briefly, these challenges include the following:

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